CURRICULUM VITAE

Balint Zoltan Kacsoh

Ph.D. Candidate, Geisel School of Medicine at Dartmouth

 

Office Address:

Department of Molecular and Systems Biology

Geisel School of Medicine at Dartmouth

609 Vail

Hanover, NH 03755

 

Skype: BalintZKacsoh

Email: balint.z.kacsoh.gr@dartmouth.edu

Orchid ID number: 0000-0001-9171-0611

Research Gate: Balint_Kacsoh2

Twitter: @BalintZKacsoh

Education

2013-Present           Geisel School of Medicine at Dartmouth, Hanover, NH, Molecular and Cellular Biology Graduate Program, PhD expected Ph.D. defense in Spring 2019.

                                    Dissertation title: Elucidating genes, circuits and behavior in a novel Drosophila social learning and memory paradigm.

                                    Mentor: Dr. Giovanni Bosco

2012                           Emory University, Atlanta, GA, M.S., Biology. M.S. defense in Spring 2012.

Dissertation title: The anti-wasp immune response across the genus Drosophila.

Mentor(s): Dr. Todd Schlenke and Dr. Nathan T. Mortimer

2012                           Emory University, Atlanta, GA, B.S., Biology

Project: The anti-wasp immune response across the genus Drosophila.

Mentor(s): Dr. Todd Schlenke and Dr. Nathan T. Mortimer

 

Research Positions

August 2013-Present                      Graduate student, Dartmouth College, Dr. Giovanni Bosco

April 2013-August 2013                  Lead Research Assistant, Dartmouth College, Dr. Giovanni Bosco

May 2012-April 2013                      Lead Research Specialist, Emory University, Dr. Todd Schlenke and Dr. Nathan T. Mortimer

January 2009-May 2012                Undergraduate Research Assistant, Emory University, Dr. Todd Schlenke and Dr. Nathan T. Mortimer

Awards and Honors

2015                           Best Poster (First Place). 1st Annual Celebration of Biomedical Research at Dartmouth (CBRaD).

2013                           Best Graduate Student Poster (Third Place): Trans-generational medication in Drosophila sechellia. 54th Annual Drosophila Research Conference, Washington D.C.

2012                           Best Undergraduate Poster (Second Place): High hemocyte load is associated with increased resistance against parasitoids in Drosophila suzukii, a relative of D. melanogaster. 53rd Annual Drosophila Research Conference, Chicago, IL.

2010                           Presidential Bronze Medal for Community Service      

2010                           Best Poster at Undergraduate Poster Symposium, Emory University

Contributions to science

Learning, memory and social behavior

As a graduate student at the Geisel School of Medicine at Dartmouth College, under the mentorship of Dr. Giovanni Bosco, my primary studies were on learning, memory, and social behavior in Drosophila melanogaster (the fruit fly). For learning and memory, we utilized an ecologically relevant stimulus (a predatory wasp), to elicit a non-associative memory, that we analyzed for decay following exposure across time. Using this assay, we find an age dependent decline of memory maintenance. For social behaviors, we find that flies exposed to predators engage in social interactions whereby naive flies learn and remember as if they had seen the predator. We have proposed that this social behavior constitutes a fly “language” and have observed both intraspecies and interspecies communication to exist throughout the genus Drosophila. The following 6 publications during my graduate school tenure (2013-present) detail these findings, in addition to other collaborative projects.

 

2018                           Kacsoh BZ, Bozler J, Bosco G (2018) Drosophila species learn dialects through communal living. Plos Genetics. doi.org/10.1371/journal.pgen.1007430. PMID:    30024883

 

                                    Preview: Manak JR (2018) Multiculturalism is good for flies, too. Plos Genetics. doi.org/10.1371/journal.pgen.1007480

 

2017                           Bozler J, Kacsoh BZ, Bosco G (2017) Nematocytes: Discovery and characterization of a novel anculeate hemocyte in Drosophila falleni and Drosophila phalerata. Plos One. doi.org/10.1371/journal.pone.0188133. PMID:    29141015

2017                           Bozler J*, Kacsoh BZ*, Chen H, Theurkauf WE, Weng Z, Bosco G (2017) A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Plos Genetics. doi.org/10.1371/journal.pgen.1007054. PMID: 29084214

2017                           Kacsoh BZ, Greene CS, Bosco G (2017) Machine Learning Analysis Identifies Drosophila Grunge/Atrophin as an Important Learning and Memory Gene Required for Memory Retention and Social Learning. G3: Genes, Genomes, Genetics. doi.org/10.1534/g3.117.300172  . PMID:    28889104

2016                           Allaway RJ, Fischer DA, de Abreu FB, Gardner TB, Gordon SR, Barth RJ, Colacchio TA, Wood M, Kacsoh BZ, Bouley SJ, Cui J, Hamilton J, Choi JA, Lange JT, Peterson JD, Padmanabhan V, Tomlinson CR, Tsongalis GJ, Suriawinata A, Greene CS, Sanchez Y, Smith KD (2016) Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites. Oncotarget. 7(13):17087-102. doi: 10.18632/oncotarget.7718. PMID: 26934555

2015                           Kacsoh BZ*, Bozler J*, Ramaswami M, Bosco G (2015) Social communication of predator-induced changes in Drosophila behavior and germ line physiology. eLife. May 13, 2015. doi.org/10.7554/eLife.07423. PMID:    25970035

2015                           Kacsoh BZ, Bozler J, Hodge S, Ramaswami M, Bosco G (2015) Non-Associative Long-Term Memory Formation in Drosophila Requires Mushroom Body Specific Functions to Maintain Predator-Induced Changes in Oviposition Behavior. Genetics. April 1, 2015 vol. 199 no. 4 1143-1157, doi:10.1534/genetics. 114.172221. PMID:    25633088

 

Innate and behavioral immunity

As an undergraduate student at Emory University, under the mentorship of Dr. Nathan Mortimer and Todd Schlenke, I studied the physiological and behavioral immune response of Drosophila melanogaster (fruit fly) and other Drosophilids in the genus Drosophila in response to predatory wasps. We uncovered physiological mechanisms of Drosophila larvae allowing successful immune responses in addition to uncovering novel wasp venom components. We also uncovered multiple unique behavioral responses of adult Drosophila to the predatory wasps. The following 7 publications during my undergraduate tenure detail these studies.

 

2014                           Kacsoh BZ, Bozler J, Schlenke TA (2014) A role for nematocytes in the cellular immune response of the Drosophilid Zaprionus indianus. Parasitology. Apr;141(5):697-715. doi: 10.1017/S0031182013001431. PMID: 24476764

2013                           Mortimer NT, Goecks J, Kacsoh BZ, Mobley JA, Bowersock GJ, Taylor J, Schlenke TA (2013) Parasitoid wasp venom SERCA regulates Drosophila calcium levels and inhibits cellular immunity. PNAS 110, doi: 9427- 9432    10.1073/pnas.1222351110. PMID: 23690612

2013                           Kacsoh BZ, Lynch ZR, Mortimer NT, Schlenke TA (2013) Fruit Flies Medicate Offspring After Seeing Parasites. Science, 2013; 339 (6122): 947 doi: 10.1126/science.1229625. PMID: 23430653

2012                           Kacsoh BZ, Schlenke TA (2012) High hemocyte load is associated with increased resistance against parasitoids in Drosophila suzukii, a relative of D. melanogaster. PLoS One 7:e34721. doi: 10.1371/journal.pone.0034721. PMID: 22529929

2012                           Milan N*, Kacsoh BZ*, Schlenke TA (2012) Alcohol consumption as self-medication against blood-borne parasites in the fruitfly. Current Biology 22:488-493. doi: 10.1016/j.cub.2012.01.045. PMID: 22342747

2012                           Mortimer NT, Kacsoh BZ, Keebaugh ES, Schlenke TA (2012) Mgat1-dependent N-glycosylation of membrane components primes Drosophila melanogaster blood cells for the cellular encapsulation response. PLoS Pathogens, 8:e1002819. doi: 10.1371/journal.ppat.1002819. PMID: 22829770

2012                           Lefèvre T, de Roode JC, Kacsoh BZ, Schlenke TA (2012) Defence strategies against a parasitoid wasp in Drosophila: fight or flight? Biol Lett. 8(2):230-3. Epub 2011 Aug 24. doi: 10.1098/rsbl.2011.0725. PMID: 21865240

*Indicates co-first authorship

 

Complete List of 13 Published Works in MyBibliography on NCBI and Google Scholar.

Manuscripts in Preparation

2018                           Kacsoh BZ, Barton S, Jiang Y, Mooney SD, Friedberg I, Radivojac P, Greene CS, Bosco G (2018) New Drosophila long-term memory genes revealed by assessing computational function prediction methods. bioRxiv. doi: 10.1101/414565

2018                           Kacsoh BZ, Bozler J, Bosco G (2018) Age dependent decline of non-associative long-term memory is dependent on FMR and PTEN function in addition to mushroom body morphology. (submitted)

2018                           Kacsoh BZ, Sadanandappa MK, Ramaswami M, Bosco G (2018) Synapsin serves as a memory extinction gene in Drosophila. (in preparation)

2018                           Bozler J, Kacsoh BZ, Bosco G (2018) Transgenerational inheritance of behavior in Drosophila (in preparation)

Abstracts and Presentations

2018                           April—Kacsoh BZ, Bozler J, Bosco G. Drosophila species learn dialects through communal living. 59th Annual Drosophila Research Conference, Philadelphia, PA.

2017*                         October—Kacsoh BZ, Greene CS, Bosco G. Machine Learning Analysis Identifies Drosophila Grunge/Atrophin as an Important Learning and Memory Gene Required for Memory Retention and Social Learning. Symposium on Biomathematics and Ecology, Education and Research. Normal, Illinois.

2016                           May— Kacsoh BZ, Bozler J, Hodge S, Bosco G. Influences of age on non-associative long-term memory and learning in Drosophila

                                    Chromatin, Epigenetics & Transcription. Cold Spring Harbor, Asia. Suzhou, China

2013                           April—Kacsoh BZ, Bozler J, Schlenke TA. A role for nematocytes in the cellular immune response of the Drosophilid Zaprionus indianus

                                    54th Annual Drosophila Research Conference, Washington D.C.

2013                           April—Kacsoh BZ, Lynch ZR, Mortimer NT, Schlenke TA. Trans-generational medication in Drosophila sechellia

                                    54th Annual Drosophila Research Conference, Washington D.C.

2012                           March—Kacsoh, BZ and Schlenke, TA. High hemocyte load is associated with increased resistance against parasitoids in Drosophila suzukii, a relative of D. melanogaster

                                    53rd Annual Drosophila Research Conference, Chicago, IL.

2012                           March—Kacsoh, BZ and Schlenke, TA. The anti-wasp immune response across the genus Drosophila.

                                    53rd Annual Drosophila Research Conference, Chicago, IL.

2010                           April—Kacsoh, BZ and Schlenke, TA. Evolutionary Patterns in immune responses of Drosophila in Parasitic Wasp Interactions

                                    Undergraduate Symposium, Emory, GA.

 

* denotes invited talk

Workshops & Career Development

2018                           59th Annual Drosophila Research Conference, Philadelphia, PA.

2017                           Symposium on Biomathematics and Ecology, Education and Research. Normal, Illinois.

2016                           Chromatin, Epigenetics & Transcription. Cold Spring Harbor, Asia. Suzhou, China

2013                           54th Annual Drosophila Research Conference, Washington D.C.

2012                           Drosophila Species Workshop, UCSD, CA.

2012                           53rd Annual Drosophila Research Conference, Chicago, IL.

Professional Societies

Genetics Society of America (2012-present)