Innate and behavioral immunity

 The Schlenke lab, 53rd Annual Drosophila Research Conference, Chicago, IL.

The Schlenke lab, 53rd Annual Drosophila Research Conference, Chicago, IL.

 Parasitoid wasp infecting Drosophila larva by Alex Wild

Parasitoid wasp infecting Drosophila larva by Alex Wild

As an undergraduate student at Emory University, under the mentorship of Dr. Nathan Mortimer (https://about.illinoisstate.edu/ntmorti/pages/default.aspx) and Todd Schlenke (https://cals.arizona.edu/research/schlenke/index.html), I studied the physiological and behavioral immune response of Drosophila melanogaster (fruit fly) and other Drosophilids in the genus Drosophila in response to predatory wasps. We uncovered physiological mechanisms of Drosophila larvae allowing successful immune responses in addition to uncovering novel wasp venom components. We also uncovered multiple unique behavioral responses of adult Drosophila to the predatory wasps.

Image of wasp by Alexander Wild (https://www.alexanderwild.com/)

 

 

 Schlenke Lab at the Chicago Bean at Drosophila Conference

Schlenke Lab at the Chicago Bean at Drosophila Conference

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What We've Achieved

2014                           Kacsoh BZ, Bozler J, Schlenke TA (2014) A role for nematocytes in the cellular immune response of the Drosophilid Zaprionus indianus. Parasitology. Apr;141(5):697-715. doi: 10.1017/S0031182013001431. PMID: 24476764

2013                           Mortimer NT, Goecks J, Kacsoh BZ, Mobley JA, Bowersock GJ, Taylor J, Schlenke TA (2013) Parasitoid wasp venom SERCA regulates Drosophila calcium levels and inhibits cellular immunity. PNAS 110, doi: 9427- 9432    10.1073/pnas.1222351110. PMID: 23690612

2013                           Kacsoh BZ, Lynch ZR, Mortimer NT, Schlenke TA (2013) Fruit Flies Medicate Offspring After Seeing Parasites. Science, 2013; 339 (6122): 947 doi: 10.1126/science.1229625. PMID: 23430653

2012                           Kacsoh BZ, Schlenke TA (2012) High hemocyte load is associated with increased resistance against parasitoids in Drosophila suzukii, a relative of D. melanogaster. PLoS One 7:e34721. doi: 10.1371/journal.pone.0034721. PMID: 22529929

2012                           Milan N*, Kacsoh BZ*, Schlenke TA (2012) Alcohol consumption as self-medication against blood-borne parasites in the fruitfly. Current Biology 22:488-493. doi: 10.1016/j.cub.2012.01.045. PMID: 22342747

2012                           Mortimer NT, Kacsoh BZ, Keebaugh ES, Schlenke TA (2012) Mgat1-dependent N-glycosylation of membrane components primes Drosophila melanogaster blood cells for the cellular encapsulation response. PLoS Pathogens, 8:e1002819. doi: 10.1371/journal.ppat.1002819. PMID: 22829770

2012                           Lefèvre T, de Roode JC, Kacsoh BZ, Schlenke TA (2012) Defence strategies against a parasitoid wasp in Drosophila: fight or flight? Biol Lett. 8(2):230-3. Epub 2011 Aug 24. doi: 10.1098/rsbl.2011.0725. PMID: 21865240